1. Heinemann, K.M., Waldron, M.K., Bigley, K.E., Lees, G.E., & Bauer, J.E. (2005). Long-chain (n-3) polyunsaturated fatty acids are more efficient than α-linoleic acid in improving electroretinogram responses of puppies exposed during gestation, lactation and weaning. Journal of Nutrition, 135, 1960—1966.
2. Reynolds, A.J., Waldron, M., Wilsson, E., Leavitt, Y., Dunlap, A., & Bailey, K. (2006). Effect of long-chain polyunsaturated fatty acid supplementation on mental stability, problem-solving ability, and learned pattern retention in young, growing dogs. Proceedings Nestlé Purina Nutrition Forum, p. 74.
1. Studzinski, C.M., Christie, L.A., Araujo, J.A., Burnham, W.M., Head, E., Cotman, C.W., & Milgram, N.W. (2006). Visuospatial function in the beagle dog: An early marker of cognitive decline in a model of human aging and dementia. Neurobiology of Learning and Memory, 86, 197—204.
2. Landsberg, G.M., Nichol, J., & Araujo, J.A. (2012). Cognitive dysfunction syndrome: A disease of canine and feline brain aging. Veterinary Clinics of North America Small Animal Practice, 42, 749—768. doi: 10.1016/j.cvsm.2012.04.003
3. London, E.D., Ohata, M., Takei, H., French, A.W., & Rapoport, S.I. (1983). Regional cerebral metabolic rate for glucose in beagle dogs of different ages. Neurobiology of Aging, 4, 121—126.
4. Schütt, T., Toft, N., & Berendt, M. (2015). Cognitive function, progression of age-related behavioral changes, biomarkers, and survival in dogs more than 8 years old. Journal of Veterinary Internal Medicine, 201, 1569—1577. doi: 10.1111/jvim.13633
5. Cory, J. (2013). Identification and management of cognitive decline in companion animals and the comparisons with Alzheimer disease: A review. Journal of Veterinary Behavior: Clinical Applications and Research, 8, 291—301.
6. Nugent, S., Tremblay, S., Chen, K.W., Ayutyanont, N., Roontiva, A., Castellano, C.A., & Cunnane, S.C. (2014).Brain glucose and acetoacetate metabolism: A comparison of young and older adults. Neurobiology of Aging, 35, 1386—1395. doi: 10.1016/j.neurobiolaging.2013.11.027
7. Pan, Y., Larson, B., Araujo, J.A., Lau, W., de Rivera, C., Santana, R., Gore, A., & Milgram, N.W. (2010). Dietary supplementation with medium-chain TAG has long-lasting cognition-enhancing effects in aged dogs. British Journal of Nutrition, 103, 1746—1754. doi: 10.1017/S0007114510000097
8. Pan, Y., Kennedy, A.D., Jonsson, T.J., & Milgram, N.W. (2018). Cognitive enhancement in old dogs from dietary supplementation with a nutrient blend containing arginine, antioxidants, B vitamins and fish oil. British Journal of Nutrition, 119, 349—358. doi: 10.1017/S0007114517003464
9. Pan, Y., Araujo, J.A., Burrows, J., de Rivera, C., Gore, A., Bhatnagar, S., & Milgram, N.W. (2013). Cognitive enhancement in middle-aged and old cats with dietary supplementation with a nutrient blend containing fish oil, B vitamins, antioxidants and arginine. British Journal of Nutrition, 110, 40—49. doi: 10.1017/S0007114512004771
1. Salvin, H.E., McGreevy, P.D., Sachdev, P.S., & Valenzuela, M.J. (2010). Under diagnosis of canine cognitive dysfunction: A cross-sectional survey of older companion dogs. Veterinary Journal, 184, 277-281.
2. Pan, Y., Larson, B., Araujo, J.A., Lau, W., de Rivera, C., Santana, R., Gore, A, & Milgram, N.W. (2010). Dietary supplementation with medium-chain TAG has long-lasting cognition-enhancing effects in aged dogs. British Journal of Nutrition, 103, 1746—1754. doi: 10.1017/S0007114510000097
3. Pan, Y., Landsberg, G., Mougeot, I., Kelly, S., Xu, H., Bhatnagar, S., & N.W. (2017). Efficacy of a therapeutic diet in dogs with signs of cognitive dysfunction syndrome (CDS): A prospective, double-blinded, placebo-controlled clinical study. Abstract N10: 2017 American College of Veterinary Internal Medicine (ACVIM) forum. Available at: https://onlinelibrary.wiley.com/action/cookieAbsent
1. Law, T.H., Davies, E.S., Pan, Y., Zanghi, B., Want, E., & Volk, H.A. (2016). A randomised trial of a medium-chain TAG diet as treatment for dogs with idiopathic epilepsy. British Journal of Nutrition, 114, 1438—1447. Erratum in: British Journal of Nutrition, 2016; 115:1696.
2. Packer, R.M.A., Volk, H.A., & Fowkes, R.C. (2017). Physiological reactivity to spontaneously occurring seizure activity in dogs with epilepsy and their carers. Physiology & Behavior, 177, 27—33. doi: 10.1016/j.physbeh.2017.04.008
3. Chang, Y., Mellor, D.J., & Anderson, T.J. (2006). Idiopathic epilepsy in dogs: Owners’ perspectives on management with phenobarbitone and/or potassium bromide. Journal of Small Animal Practice, 47, 574—581.
4. Packer, R.M.A., McGreevy, P.D., Pergande, A., & Volk, H.A. (2018). Negative effects of epilepsy and antiepileptic drugs on the trainability of dogs with naturally occurring idiopathic epilepsy. Applied Animal Behaviour Science, 200, 106—113. doi: 10.1016/j.applanim.2017.11.008
5. Packer, R.M.A., McGreevy, P.D., Salvin, H.E., Valenzuela, M.J., Chaplin, C.M., & Volk, H.A. (2018). Cognitive dysfunction in naturally occurring canine idiopathic epilepsy. doi: 10.1371/journal.pone.0192182
6. Winter, J., Packer, R.M.A., & Volk, H.A. (2018c). Preliminary assessment of cognitive impairments in canine idiopathic epilepsy. Veterinary Record. 182(22), 663. doi: 10.1136/vr.104603
7. Kim, D.Y., Simeone, K.A., Simeone, T.A., Pandya, J.D., Wilke, J.C., Ahn, Y., Geddes, J.W., Sullivan, P.G., & Rho, J.M. (2015). Ketone bodies mediate antiseizure effects through mitochondrial permeability transition. Annals of Neurology 78, 77—87. doi: 10.1002/ana.24424
8. Masino, S.A., Li, T., Theofilas, P., Sandau, U.S., Ruskin, D.N., Fredholm, B.B., Geiger, J.D., Aronica, E., & Boison, D. (2011). A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors. Journal of Clinical Investigation 121, 2679—2683. doi: 10.1172/JCI57813
9. Wlaź, P., Socała, K., Nieoczym, D., Łuszczki, J.J., Zarnowska, I., Zarnowski, T., Czuczwar, S.J., & Gasior, M. (2012). Anticonvulsant profile of caprylic acid, a main constituent of the medium-chain triglyceride (MCT) ketogenic diet, in mice. Neuropharmacology 62, 1882—1889. doi: 10.1016/j.neuropharm.2011
10. Neal, E.G., Chaffe, H., Schwartz, R.H., Lawson, M.S., Edwards, N., Fitzsimmons, G., & Cross, J.H. (2009). A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy. Epilepsia 50, 1109—1117. doi: 10.1111/j.1528-1167.2008.01870.x
11. Packer, R.M.A., Law, T.H., Davies, E., Zanghi, B., Pan, Y., & Volk, H.A. (2016). Effects of a ketogenic diet on ADHD-like behavior in dogs with idiopathic epilepsy. Epilepsy & Behavior, 55, 62—68. doi: 10.1016/j.yebeh.2015.11.014